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Chemotactic factor to polymorphonuclear leukocytes in the human lens 6. chemotactic factor in low molecular weight fractions



Chemotactic factor to polymorphonuclear leukocytes in the human lens 6. chemotactic factor in low molecular weight fractions



Nippon Ganka Gakkai Zasshi 90(8): 1110-1114



100 fractions were revealed from water soluble low molecular weight fractions (less than MW12400) filtered by collodion bag with Sephadex G-25 and high performance liquid chromatography (HPLC). Chemotaxis assay was done on these 100 fractions with same method as previous reports. The total amino acid composition of 5 fractions of 19 fractions showed high chemotactic activity to polymorphonuclear leucocytes were analysed. Common amino acids of all these fractions were asparatic acid, serine, glutamic acid, and glycine. Common amino acids of high chemotactic short peptides of .gamma.L fraction digested with trypsin were asparatic acid, serine, glutamic acid, glycine, and lysine. So, asparatic acid, serine, glutamic acid, and glycine were common in chemotactic peptides of .gamma.L fraction and low molecular weight fractions (less than MW 12400). These four amino acids were also detected from neutrophil chemotactic factors or Escherichia coli, and three of them were detected from chemotactic factors of human lung tissue. So, these amino acids were suggested to be active site of chemotactic peptides to polymorphonuclear leucocytes.

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Accession: 004941769

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PMID: 3532724


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