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Chromosomal aberrations and fetotoxic effects of atmospheric arsenic exposure in mice

Chromosomal aberrations and fetotoxic effects of atmospheric arsenic exposure in mice

Journal of Applied Toxicology 5(2): 61-63

Fetal chromosomal damage and toxicity were investigated in mice exposed to the atmospheric concentrations of 28.5, and 0.26 mg/m3 As for 4 h/day on the 9th, 10th, 11th and 12th days of gestation. On the 18th day, the fetuses were removed, and the following parameters were examined: the number of dead fetuses, retardation in growth, osteogenesis and chromosomal aberrations in liver cells. Exposure to As2O3 at 28.5 mg/m3 caused fetotoxic effects and chromosomal damage, while the 2 lower exposures produced no significant changes with the exception of a slight decrease (9.9 and 3.1%, respectively) in fetal weight.

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Accession: 004950657

Download citation: RISBibTeXText

PMID: 3998376

DOI: 10.1002/jat.2550050204

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