Chromosomal damage caused by cyclophosphane in bone marrow cells of an aplastic anemia patient during preparation for an allogeneic bone marrow transplant

Pyatkin, E.K.; Baranov, A.E.

Problemy Gematologii i Perelivaniya Krovi 22(3): 12-16


Accession: 004951045

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The peripheral blood lymphocytes and hemopoietic tissue cells were studied in a patient suffering from aplastic anemia to whom was transplanted allogeneic bone marrow from a donor of the opposite sex, identical with the recipient by HLA and MLC antigens. Multiple aberrations of chromosomal type were revealed in analysis of chromosomes of the bone marrow cells on the 7th day after the transplantation (on the 9th day after stopping cyclophosphane administration). Results of hematological study confirmed the cytogenetic data on the fact that, despite severe generalized infection caused by Candida albicans, which developed during the posttransplantation period, the donor bone marrow proved to take.