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Chronological development of the permeability of the blood cerebro spinal fluid barrier as evaluated from the serum cerebro spinal fluid concentration ratio of proteins



Chronological development of the permeability of the blood cerebro spinal fluid barrier as evaluated from the serum cerebro spinal fluid concentration ratio of proteins



Nichidai Igaku Zasshi 39(4): 365-372



The permeability of the blood CSF barrier to proteins is presumably high in the fetal and neonatal period and gradually decreases to the adult level after birth. Development of the blood CSF barrier with age was evaluated from the serum/CSF concentration ratios of large protein (.alpha.2-macroglobulin) and of small protein (albumin), respectively. CSF and serum were obtained simultaneously from 49 children aged from 9 days-10 1/2 yr. The CSF and serum concentrations of .alpha.2-macroglobulin and albumin were measured by rocket immunoelectrophoresis. Both ratios were very low in the neonatal period (.alpha.2-macroglobulin, 415 .+-. 187; albumin, 70 .+-. 22) and gradually increased to constant values at .apprx. 1-2 yr old (.alpha.2-macroglobulin, .apprx. 2000-3000; albumin, .apprx. 350-450). The permeability of protein molecules from the blood to CSF is high in the neonatal period but gradually decreases with age. The blood CSF barrier to protein molecules develops with age and reaches the adult level at 1-2 yr old regardless of the MW and molecular radius of the proteins.

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