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Chronotherapeutic study of sulindac single daily 400 milligram dose in arthrosis of the lower limbs a randomized double blind multicenter trial



Chronotherapeutic study of sulindac single daily 400 milligram dose in arthrosis of the lower limbs a randomized double blind multicenter trial



Semaine des Hopitaux 62(33): 2683-2690



A chronotherapeutic study of sulindac, 400 mg/d in a single daily dose, was carried out using a double-blind design in 105 patients with arthrosis of the lower limbs. Sulindac was taken every morning (n = 52 cases) or every evening (n = 53 cases) for 14 days. Results were as follows: 1) the satisfactory effectiveness and tolerance of once-daily sulindac in this degenerative disease were confirmed; 2) effectiveness and tolerance of a single daily 400 mg dose of sulindac were identical whether the drug was taken in the evening or in the morning; 3) comparison of the two groups of patients failed to disclose any significant difference between effectiveness/tolerance ratios or to identify a preferential dosage time for sulindac in lower limb arthrosis.

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