Ciprofloxacin concentrations in human aqueous humor following intravenous administration
Behrens-Baumann, W.; Martell, J.
ChemoTherapy 33(5): 328-330
1987
ISSN/ISBN: 0009-3157
PMID: 3665631
DOI: 10.1159/000238517
Accession: 004957972
16 patients received an intravenous infusion of 200 mg ciprofloxacin 1, 2, 3 and 6 h, respectively, before cataract extraction. This dosage produced mean aqueous humor levels of 0.165 +/- 0.09 and 0.126 +/- 0.028 microgram/ml after 1 and 3 h, respectively. The mean serum levels were 1.760 +/- 0.873 and 0.854 +/- 0.283 microgram/ml after 1 and 3 h, respectively. These levels are above the minimum inhibitory concentration of ciprofloxacin for sensitive organisms.