+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Clinical and prognostic value of quantified fibrosis in alcoholic liver cirrhosis

Clinical and prognostic value of quantified fibrosis in alcoholic liver cirrhosis

Revista Espanola de las Enfermedades del Aparato Digestivo 68(5): 413-419

In order to study its clinical and prognostic value, the surface of fibrous septa present in the liver biopsy of 129 patients with alcoholic cirrhosis (99 male and 30 female, average age 52,47 .+-. 1) was measured with a semiautomatic image analyzer LEITZ ASM. The degree of fibrosis was related (100 .times. fibrosis/parenchymas + fibrosis) to several clinical and biologic parameters and the patients were classified in three groups (I, II, III, the last meaning the highest degree of decompensation) according to the results. The degree of fibrosis was much greater in the patients of group III (39.68 .+-. 2.1) than in those of group II (30.2 .+-. 2.16) (t = 4.3; p < 0.001) and group I (25.77 .+-. 2.27) (t = 6.53; p < 0.001). We found a statistically significant correlation between prothrombin activity and fibrosis in all 129 patients (r = 0.44; p < 0.001) and between fibrosis and gammaglobulin (r = 0.18; p < 0.005). Eighty-five out of the 129 patients were followed-up during 619.1 .+-. 533.7 days. Thirty of them died, 26 with liver failure: ten died before 250 days, 18 before 500 days, 20 before 750 days and 22 before 1.000 days since the biopsy was done. The differences between the degree of fibrosis of those patients who liver over 250, 500, 750 and 1.000 days and those who died before these delays were compared among them and to the differences of prothrombin activity, albumin levels, gammaglobulin and bilirubin in the above mentioned 4 pairs of patient groups. Fibrosis was greater in patients dying before 250 days (t = 2.2; p < 0.05), 500 days (t = 3.23; p < 0.005), 750 days (t = 2.45; p < 0.02) and 1000 days (t = 3.17; p < 0.005) than in those that survived these periods of time. The differences obtained for fibrosis were slightly higher than those obtained for prothrombin activity and much higher than those obtained for albumin, gammaglobulin and bilirubin. We therefore conclude that the degree of fibrosis is much greater in decompensated patients and that qualification of fibrosis has a certain prognostic value with respect to the survival of the cirrhotic patient at short and mean delay, slightly higher than that of prothrombin and clearly superior to that of bilirubin, albumin and gammaglobulin.

(PDF emailed within 1 workday: $29.90)

Accession: 004965907

Download citation: RISBibTeXText

Related references

Tu1036 The Cirrhosis Risk Score is Not Associated With Liver Fibrosis/Cirrhosis and Fibrosis Progression in Chinese Non-Alcoholic Fatty Liver Disease Patients. Gastroenterology 142(5): S-1017, 2012

230/355 Improvement of Inflammatory Biomarkers, Liver Fibrosis, Liver Functions & Clinical Parameters With Three Months Supplementation of (220mg) Zinc Sulfate for Alcoholic Cirrhosis (Zac) - Clinical Trial. Gastroenterology 148(4): S-972, 2015

The thyroid hormones in alcoholic liver cirrhosis. Clinical and prognostic aspects. Minerva Medica 73(35): 2275-2278, 1982

Liver cirrhosis.An advance on diagnosis and treatment.4.Clinical feature of alcoholic cirrhosis.The comparison with viral liver cirrhosis. Nihon Naika Gakkai Zasshi 80(10): 1587-1591, 1991

Clinical problems of alcoholic cirrhosis. I. Biological and clinical characteristics of the alcoholic cirrhosis of the liver. Acta Medica Iugoslavica 28(4): 339-353, 1974

Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics. Drug Metabolism and Disposition: the Biological Fate of Chemicals 44(11): 1752-1758, 2016

Colchicine for alcoholic and non-alcoholic liver fibrosis and cirrhosis. Cochrane Database of Systematic Reviews 2001(3): Cd002148, 2001

Colchicine for alcoholic and non-alcoholic liver fibrosis or cirrhosis. Liver 21(2): 129-136, 2001

Colchicine for alcoholic and non-alcoholic liver fibrosis and cirrhosis. Liver 20(3): 262-266, 2000

Colchicine for alcoholic and non-alcoholic liver fibrosis and cirrhosis. Cochrane Database of Systematic Reviews 2005(2): Cd002148, 2005

Prognostic value of clinical variables and liver histology for development of fibrosis and cirrhosis in autoimmune hepatitis. Scandinavian Journal of Gastroenterology 52(3): 321-327, 2016

Mortality rate of alcoholic liver disease and risk of hospitalization for alcoholic liver cirrhosis, alcoholic hepatitis and alcoholic liver failure in Australia between 1993 and 2005. Internal Medicine Journal 41(1a): 34-41, 2011

Foc5-5Morphometrical Quantification Of Fibrosis Correlates With Clinical Cirrhosis Stage And Predicts Long-Term Survival In Patients With Alcoholic Liver Disease. Alcohol and Alcoholism 50(suppl 1): i40.3-i40, 2015

Alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis. Drinking behavior and incidence of clinical, clinico-chemical and histological findings in 282 patients. Deutsche Medizinische Wochenschrift 109(40): 1516-1521, 1984

Functional liver imaging with 99Tcm-galactosyl-neoglycoalbumin (NGA) in alcoholic liver cirrhosis and liver fibrosis. Nuclear Medicine Communications 12(6): 507-517, 1991