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Clinical and upper gastro intestinal effects of sulindac indomethacin and paracetamol plus dextro propoxyphene in patients with osteo arthritis



Clinical and upper gastro intestinal effects of sulindac indomethacin and paracetamol plus dextro propoxyphene in patients with osteo arthritis



European Journal of Rheumatology & Inflammation 3(3): 222-231



Patients with osteoarthritis were given either indomethacin, 25 mg 3 times daily, sulindac, 200 mg twice daily or paracetamol plus dextropropoxyphene (Distalgesic, Dista Products) 2 tablets 3 times daily. Clinical symptoms and signs were assessed by methods including upper gastrointestinal (UGIT) fibreoptic endoscopy and histological grading of inflammation in gastric and duodenal biopsies. All 3 compounds improved joint symptoms and function. Indomethacin produced most symptoms referable to the UGIT, sulindac the least. Indomethacin and sulindac were equally likely to produce UGIT inflammation in gastrointestinal biopsies. Distalgesic was the least likely to do so. Sulindac apparently has effects comparable to indomethacin on joints and UGIT but produces fewer symptoms. Both drugs are as effective as Distalgesic in analgesic potential in patients with osteoarthritis.

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Accession: 004966112

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