Clinical implications of the measurement of free thyroid hormones in thyroid disease

Baldet, L.; Jaffiol, C.

Clinical Endocrinology 13(4): 393-400

1980


ISSN/ISBN: 0300-0664
PMID: 6777093
DOI: 10.1111/j.1365-2265.1980.tb03401.x
Accession: 004969836

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Abstract
The dialysable fractions of T3 and DFT3/TBG in 49 individuals (9 hyperthyroid, 10 euthyroid, 10 hypothyroid patients, 10 pregnant women and 10 subjects taking oral contraceptives) was best described in both instances by 2 regression curves. The 1st regression showed that DFT4 and DFT3 were inversely correlated with TBG. The 2nd regression described the 9 most biochemically toxic patients. They were statistically independent of the first, and being almost perpendicularly disposed to the TBG axis were interpreted as saturation curves. Analysis of the discriminant value of free thyroid hormone levels (AFT3, AFT4) derived from DFT3 and DFT4 showed that free thyroid hormone measurements were in no way superior to total thyroid hormone measurement in the biochemical diagnosis of hyper- and hypothyroidism. There were no significant differences in DFT3, DFT4, AFT3 and AFT4 between patients and controls in subjects whose only abnormality was a decreased (n = 18) or exaggerated (n = 9) thyrotropin response in the thyroliberin test. Mean total T3 and AFT3 were significantly higher than controls in patients with hot nodules who were hyperthyroid (n = 9) but only AFT3 was higher in corresponding patients (n = 9) who were euthyroid.

Clinical implications of the measurement of free thyroid hormones in thyroid disease