Clinical significance of lecithin cholesterol acyltransferase and high density lipoprotein cholesterol in liver disease

Fukuda, M.

Medical Journal of Kobe University 44(4): 107-116


Accession: 004971728

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Lecithin cholesterol acyltranferase (LCAT) and high density lipoprotein (HDL) are synthesized in the liver and released into the circulation. After the esterification of free cholesterol, LCAT is taken up by the liver with HDL and metabolized there. The clinical significance of LCAT and HDL-cholesterol in liver diseases was investigated. Total and free cholesterol, HDL-cholesterol, cholinesterase and LCAT were measured in 118 patients with liver diseases and 80 normal subjects. In patients with acute hepatitis, liver cirrhosis and hepatoma, HDL-cholesterol level and LCAT activity were lower than each control value, respectively. There was positive correlation between LCAT activity and cholinesterase level in patients with liver cirrhosis. There was negative correlation between LCAT and free cholesterol level in patients with liver cirrhosis. LCAT activity decreased in acute phase of acute hepatitis, but recovered gradually to normal value. An investigation on the serum LCAT activity, HDL-cholesterol level and their combination with other parameters appeared to be applicable in estimating the stage and severity of liver diseases.