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Clinical studies on cross resistance of gram negative bacilli isolated from urinary tract infections against amino glycosides



Clinical studies on cross resistance of gram negative bacilli isolated from urinary tract infections against amino glycosides



Nishinihon Journal of Urology 41(6): 1069-1073



Gram-negative bacilli (404 strains) isolated from inpatients with urinary tract infections at the Urological Department of Okayama University Hospital [Japan] from Jan. 1977-Dec. 1978 were examined for cross resistance to aminoglycosides. The strains consisted of 180 Pseudomonas sp., 139 Serratia, 27 Escherichia coli, 35 Proteus sp. and 23 Klebsiella sp. Pseudomonas sp. showed resistance to GM [gentamicin] (44.4%), DKB [dibekacin] (73.9%) and AMK [amikacin] (10.6%); about half of the strains (44.4%) had cross resistance between GM and DKB, but only 6.7% between GM and AMK. Serratia showed resistance to GM (5.8%), DKB (91.4%) and AMK (56.1%); 56.1% were cross resistant to DKB and AMK. Some 48.2% of E. coli strains, 45.7% of Proteus sp. and 69.6% of Klebsiella sp. were simultaneously sensitive to GM, DKB and AMK. Eighty strains of Pseudomonas sp., 8 of Serratia, 5 of E. coli, 4 of Proteus sp. and 3 of Klebsiella sp. were resistant to GM; 85% of these GM resistant strains were sensitive to AMK. There was no significant cross resistance between GM and AMK in this series.

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