+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Clinical studies on digoxin intoxication 2. relationship between plasma and erythrocyte digoxin concentrations



Clinical studies on digoxin intoxication 2. relationship between plasma and erythrocyte digoxin concentrations



Japanese Heart Journal 21(4): 497-504



The digoxin concentration in both plasma and erythrocytes was measured in 75 patients by radioimmunoassay during digoxin maintenance therapy. Mean plasma digoxin concentration was 0.90 ng/ml and mean erythrocyte digoxin concentration was 1.44 ng/ml in 75 patients. The ratio of digoxin concentration of erythrocyte to plasma during maintenance therapy was 2.24 in all patients, 1.63 in patients with therapeutic plasma digoxin levels, and 3.52 in patients with subtherapeutic plasma levels. There was a significant correlation between erythrocyte and plasma digoxin concentrations in therapeutic plasma levels (r = 0.53, P < 0.001). Patients on maintenance digoxin therapy were classified into 6 groups according to plasma and erythrocyte digoxin concentrations. In group I, 7 patients with both low plasma and erythrocyte digoxin concentrations were poorly controlled in respect to heart failure. In group II, 19 patients with low plasma and medium erythrocyte digoxin concentrations failed to show compliance. In group III, 3 patients with therapeutic plasma and low erythrocyte digoxin levels showed poor compliance. In group IV, 41 patients with both medium plasma and erythrocyte digoxin levels were well controlled in respect to heart failure, and all were compliant. Careful observation was required to avoid digoxin intoxication in group V, with therapeutic plasma and high erythrocyte digoxin concentrations, and in group VI with high plasma and high erythrocyte digoxin concentrations.

(PDF emailed within 1 workday: $29.90)

Accession: 004972499

Download citation: RISBibTeXText

PMID: 7420733


Related references

Relationship between digoxin plasma concentrations and frequency of digoxin intoxication. Arzneimittel-Forschung 31(9): 1469-1471, 1981

The diagnostic value of determination of intraerythrocytic sodium and potassium concentrations versus plasma digoxin concentration in digoxin intoxication. Acta Medica Scandinavica 213(5): 357-362, 1983

Digoxin intoxication: the relationship of clinical presentation to serum digoxin concentration. Journal of Clinical Investigation 49(12): 2377-2386, 1970

Suppression of total digoxin concentrations by digoxin-like immunoreactive substances in the MEIA digoxin assay. Elimination of negative interference by monitoring free digoxin concentrations. American Journal of Clinical Pathology 111(3): 406-410, 1999

Clinical significance of digoxin in erythrocytes for diagnosis of digitalis toxicity and relations among plasma erythrocyte and myo cardial digoxin levels. Japanese Circulation Journal 45(8): 973-974, 1981

Clinical studies on digoxin intoxication serum concentration of digoxin in the elderly and the effect of diuretics. Japanese Heart Journal 21(3): 341-356, 1980

Digoxin and a clinical evaluation of three digoxin methods, microgenic CEDIA Digoxin Plus, Dade Stratus digoxin and Technicon Immuno 1. Clinical Chemistry 40(6): 1082, 1994

Relationship of serum and myocardial digoxin concentration to electrocardiographic estimation of digoxin intoxication. Journal of Clinical Pharmacology 18(1): 10-15, 1978

Kinetics of the Fab fragments of digoxin antibodies and of bound digoxin in patients with severe digoxin intoxication. European Journal of Clinical Pharmacology 30(5): 527-533, 1986

Measurement of digoxin in plasma and its use in diagnosis of digoxin intoxication human. British Medical Journal (5639): 286-289, 1969

Everest MS: Measurement of digoxin in plasma and its use in diagnosis of digoxin intoxication. British Medical Journal 1(5639): 286-289, 1969

Digoxin intoxication in newborns correlation with digoxin plasma concentration. Monatsschrift für Kinderheilkunde 126(3): 148-152, 1978

Measurement of Digoxin in Plasma and its use in Diagnosis of Digoxin Intoxication. Bmj 1(5639): 286-289, 1969

Studies on digitalis intoxication by means of discriminant function and clinical significance of serum digoxin concentrations. Japanese Circulation Journal 44(8): 649, 1980

Estimating concentrations of total digoxin and digoxin-like immunoreactive substances in volume-expanded patients being treated with digoxin. Therapeutic Drug Monitoring 18(1): 34-39, 1996