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Clinical studies on patients with sjogrens syndrome 1. labial salivary gland biopsies and xerostomia in patients with sjogrens syndrome



Clinical studies on patients with sjogrens syndrome 1. labial salivary gland biopsies and xerostomia in patients with sjogrens syndrome



Okayama Igakkai Zasshi 94(1-2): 51-58



Labial salivary gland specimens were obtained from 470 patients with sicca syndrome, collagen diseases and other diseases, and were analyzed according to histological criteria of Chisholm and Mason. Abnormal findings were observed in the labial salivary gland in 133 (55.0%) of 242 patients with xerostomia that were significantly higher (P < 0.001) compared with 64 (28.1%) of 228 patients without xerostomia. The histological findings correlated well with the findings of parotid sialography (P < 0.001). In patients without xerostomia, abnormal histological findings were frequently observed in collagen disease: 8 (13.1%) of 61 patients with rheumatoid arthritis; 17 (22.7%) of 75 patients with systemic lupus erythematosus; and 9(30.0%) of 30 patients with mixed connective tissue disease. In 193 patients with abnormal findings in the salivary gland, the average age of the patient with xerostomia at biopsy was higher than that of the patients without symptoms (P < 0.001). Since it remains unclear whether the patients who show abnormal findings of labial salivary gland without xerostomia have Sjogren's syndrome, or whether these histological abnormalities represent part of the basic disease processe, these patients should be observed under the term of subclinical Sjogren's syndrome.

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Accession: 004972588

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