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Clinical studies on patients with sjogrens syndrome 2. characteristics of patients with sjogrens syndrome and the effect of cortico steroid therapy



Clinical studies on patients with sjogrens syndrome 2. characteristics of patients with sjogrens syndrome and the effect of cortico steroid therapy



Okayama Igakkai Zasshi 94(1-2): 59-72



Clinical and laboratory findings of 160 patients with definite Sjogren's syndrome were analyzed, and the effect of corticosteroid therapy on these patients was examined. Of these, 159 were female and the average age at the time of diagnosis was 46.2 .+-. 12.2 yr. The past histories disclosed gynecological diseases in 44 patients (29.9%), appendicitis in 32 (21.8%), sinusitis in 10 (6.8%), and pleuritis in 10 (6.8%). Complaints of oral dryness and decreased saliva were common in 73.8% of patients. Failure of lacrimation, redness, film and increased dental caries were present in 20-30% of patients. Systemic manifestations such as arthralgia, fever, Raynaud's phenomenon and lymph node swelling were frequent. Abnormalities of Schirmer's test and gum test, and histological findings of salivary glands and of the sialogram were found in 80% of patients; hyper .gamma.-globulinemia was present in 81%. Anti-SS-A antibody, rheumatoid factor, and total antinuclear antibodies were positive in 60-70%. Corticosteroid was effective for patients with the sicca syndrome; it relieved the symptoms of dry eye and dry mouth, and also tended to decrease the inflammation of the salivary glands. Serum .gamma.-globulin and amylase were lower immediately after the corticosteroid treatment.

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