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Colorimetric method for the estimation of menadione or menadione sodium bi sulfite in pharmaceutical dosage forms


Colorimetric method for the estimation of menadione or menadione sodium bi sulfite in pharmaceutical dosage forms



Indian Journal of Pharmacy 37(6): 141-143



ISSN/ISBN: 0019-5472

The method is based on measuring the absorbance at 535 nm of the stable violet color produced by the interaction of menadione (M) or menadione sodium bisulfite (MSB) with 1-phenyl-3-methylpyrazole-5-one in the presence of phosphate buffer of pH 7.8. The Beer-Lambert law was obeyed over the concentration range of 5-20 mcg (M)/ml. The SDs were .+-. 0.167 and .+-. 0.209 calculated on 2 samples containing 5 and 20 mg (MSB)/tablet. It also afforded improvements in sensitivity, ease and speed over the official method.

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Accession: 004986444

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Related references

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