Combined action of pyrazole and ethanol on a rat liver: histochemical and ultrastructural study
Składziński, J.; Beskid, M.
Folia Histochemica et Cytochemica 16(1): 13-18
ISSN/ISBN: 0015-5586 PMID: 640510 Accession: 004987512
The effect on a rat liver of combined administration of pyrazole and ethanol was studied histochemically and by electron microscopy. The study revealed strong hepatotoxic action of pyrazole combined with ethanol. Feeding with ethanol alone induces slight alterations in the liver, pyrazole alone affects the liver but slightly, whereas a combined administration of pyrazole and ethanol both by light and electron microscopy examination revealed a strong toxic action leading to severe damage of the liver cells including necrosis.