Combined action of ultrasound and ionizing radiation on yeast saccharomyces cerevisiae cells
Petin, V.G.; Komarov, V.P.; Skvortzov, V.G.
Radiation and Environmental Biophysics 18(1): 45-56
ISSN/ISBN: 0301-634X Accession: 004987517
Observations were reported of synergistic relationships between ultrasound [US] and .gamma.-irradiation of stationary phase cultures of S. cerevisiae of different strains. The .gamma.-ray dose was applied before or after the sound. The extent of synergism depended upon the sequence of application; it was smaller for (US + .gamma.-ray)-exposure in comparsion with (.gamma.-ray + US)-treatment. The combined action of both modalities had smaller or no synergistic effect for mutant (rad51) yeast cells incapable of recovery. Possible mechanisms for ultrasound radiosensitization of yeast cells may involve the reduced capacity of cells to recover damages resulted from the combined action and/or the enhanced expression of lethal damage.