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Comparative beta adrenoceptor blocking effects and pharmaco kinetics of sotalol and propranolol in healthy volunteers



Comparative beta adrenoceptor blocking effects and pharmaco kinetics of sotalol and propranolol in healthy volunteers



Therapie (London/Paris) 37(3): 259-267



The .beta.-adrenoceptor blocking effects of sotalol (240 mg as a single oral dose) were compared with those of propranolol (80 mg as a single oral dose) and a placebo in a double-blind trial involving 6 healthy volunteers. Heart rate (HR), systolic blood pressure (SBP), double product (HR .times. SBP) and peak expiratory flow rate (PEFR) were measured at rest and after vigorous exercise before and at intervals up to 24 h after oral administration of the drugs. Plasma renin activity at rest (PRA) and plasma levels of sotalol and propranolol were also measured. Sotalol is a noncardioselective .beta.-adrenoceptor blocking drug, antagonizing exercise-induced tachycardia, reducing exercise-induced increase in PEFR and decreasing PRA. The .beta.-adrenolytic potency of sotalol was .apprx. 1/3 that of propranolol, but the duration of its effect was longer. There was an excellent correlation between biological activity and plasma levels for both drugs.

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Accession: 004992264

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PMID: 6753226


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