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Comparative efficacy of pirprofen and aspirin in rheumatoid arthritis


, : Comparative efficacy of pirprofen and aspirin in rheumatoid arthritis. Journal of Clinical Pharmacology 19(1): 56-63

A six-month double-blind, randomized, parallel-design trial comparing pirprofen, a new nonsteroidal antiinflammatory drug, with aspirin in patients with rheumatoid arthritis is described. The dose of pirprofen, a phenylpropionic acid derivative, was 600 mg per day; the dose of aspirin was 3600 mg per day. Pirprofen was found to be as effective as aspirin in improving the modified articular index, swelling joint index, grip strength, walking time, and duration of morning stiffness. Fewer patients receiving pirprofen reported drug-related side effects than those receiving aspirin, however, the difference was not statistically significant (P less than 0.1). There was no significant difference between groups in the incidence of positive stool guaiac tests (three of 17, pirprofen; five of 18, aspirin). Pirprofen was found to be as safe and effective as aspirin in the management of patients with rheumatoid arthritis.

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Accession: 004994438

PMID: 368086

DOI: 10.1002/j.1552-4604.1979.tb01617.x

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Related references

Davis, J.D.; Struth, A.G.; Turner, R.A.; Pisko, E.J.; Ruchte, I.R., 1979: Pirprofen and aspirin in the treatment of rheumatoid arthritis. Pirprofen (800 mg/day) or aspirin (3,600 mg/day) was administered in double-blind fashion for up to one year to 40 adult outpatients with rheumatoid arthritis, after a short, single-blind placebo period. There were no statistically significant dif...

Struth A.; Pisko E.; Turner R.; Davis J., 1978: Comparison of pirprofen and aspirin in rheumatoid arthritis. Clinical Pharmacology & Therapeutics 23(1): 131

Singleton, C.M.; Wild, J.H., 1980: A double-blind comparison of aspirin and pirprofen in the treatment of rheumatoid arthritis. Pirprofen (600 mg, 800 mg) and aspirin (3,600 mg) were compared in 30 outpatients (33-67 yr old) with definite or classical rheumatoid arthritis. After 10 wk of treatment with either pirprofen dose, the number of painful joints, grip strength, and...

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