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Comparative in vitro activity of norfloxacin mk 0366 against gram negative bacilli isolated from urinary tract infections



Comparative in vitro activity of norfloxacin mk 0366 against gram negative bacilli isolated from urinary tract infections



Drugs under Experimental & Clinical Research 9(5): 331-336



The in vitro activity of norfloxacin was evaluated against gram-negative bacilli isolated from human urinary tract infections and compared with that of other compounds commonly used for treatment of such infections: nalidixic and pipemidic acid, nitrofurantoin, ampicillin, cephalothin, gentamicin and cotrimoxazole. The minimum inhibitory concentrations for 108 clinical isolates were determined by the agar dilution technique. Norfloxacin was the most effective antimicrobial agent, inhibiting 50 and 90% of the isolates at concentrations of 0.25 .mu.g/ml and 64 .mu.g/ml, respectively. It activity was remarkable against Escherichia coli, Klebsiella, Enterobacteria, Serratia and most Pseudomonas strains, but quite limited against indole-positive Proteus.

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Accession: 004995936

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