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Comparative study on the effects of a hypo glycemic 2 substituted 2 imidazoline derivative dg 5128 and tolbutamide on insulin secretion from and insulin synthesis in the isolated rat pancreatic islets



Comparative study on the effects of a hypo glycemic 2 substituted 2 imidazoline derivative dg 5128 and tolbutamide on insulin secretion from and insulin synthesis in the isolated rat pancreatic islets



Biochimica et Biophysica Acta 677(2): 263-268



2[2-(4,5-Dihydro-1H-imidazol-20yl)-1-phenylethyl]pyridine dihydrochloride sesquihydrate (DG 5128) stimulated the glucose-primed insulin secretion from the isolated rat pancreatic islets throughout the incubation period, unlike tolbutamide which stimulated it only in the initial phase of incubation. The effect of DG 5128 was more pronounced at a higher glucose concentration (5 mg/ml). In the islet perifusion study, DG 5128 also stimulated the glucose-induced insulin secretion in both the 1st and the 2nd phases of the reaction in contrast to tolbutamide which stimulated only the 1st phase of insulin secretion from the perifused islets. DG-5128 had no significant effect on the glucose-stimulated increase in incorporation of [3H]leucine into the proinsulin and insulin fractions, while tolbutamide significantly inhibited the incorporation especially at a low glucose concentration (1 mg/ml). DG 5128 apparently is a new class of hypoglycemic agent with a unique mode of action different from the known hypoglycemics previously reported.

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Accession: 005002064

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PMID: 7028134


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