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Comparison of hydrocortisone and cortico sterone action on chromatin histone and dna biosynthesis in the regenerating rat liver



Comparison of hydrocortisone and cortico sterone action on chromatin histone and dna biosynthesis in the regenerating rat liver



Problemy Endokria 22(3): 69-72



Thymidine incorporation into DNA was depressed and glycine incorporation into histone proteins was decreased after treatment of rats with hydrocortisone and corticosterone for 4 days (3 days before and on the day of partial hepatectomy). No significant differences in the action of these glucocorticoids on biosynthesis of DNA and histones during regeneration were noted. There was no decrease in histones and nucleoprotein in comparison with controls 6 h after the operation at a time when synthesis of DNA-like RNA was elevated. Apparently DNA synthesis was not necessary for biosynthesis of histone proteins, or in any case not necessary for the biosynthesis of the arginine-rich fraction of histones.

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Accession: 005008617

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