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Comparison of inhibitory activity of various organo phosphorus compounds against acetyl cholin esterase and neuro toxic esterase of hens with respect to delayed neuro toxicity

Biochemical Pharmacology 29(20): 2721-2728

Comparison of inhibitory activity of various organo phosphorus compounds against acetyl cholin esterase and neuro toxic esterase of hens with respect to delayed neuro toxicity

A variety of organophosphorus (OP) compounds with and without delayed neurotoxicity were examined for inhibitory power against neurotoxic esterase (NTE) and acetylcholinesterase (AchE) of hen brain in vitro and in vivo. Delayed neurotoxicity induced by OP compounds correlated with high inhibition of NTE in vivo, but in vitro studies comparing I50 [median inhibitory concentration] for both enzymes did not provide a guide to evaluation of delayed neurotoxicity. Single oral administration of delayed neurotoxic EPN (ethyl 4-nitrophenyl phenylphosphonothionate), leptophos and TOCP [tri-o-cresyl phosphate] caused > 80% inhibition of brain NTE at neurotoxic doses, but non-delayed neurotoxic methyl parathion, fenitrothion and cyanophos caused weak inhibition at near lethal doses which gave rise to severe inhibition of brain AchE. A delayed neurotoxic dose of (-)-EPN caused more severe inhibition of brain NTE compared to the same dose of the non-delayed neurotoxic (+)-isomer. A few compounds produced severe inhibition of NTE at non-delayed neurotoxic doses. Hens paralyzed by repeated administration of a low level of leptophos showed significant decreases in NTE activity of the brain and spinal cord.

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Accession: 005008930

PMID: 7437078

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