Comparison of myo cardial metabolic effects of ischemia and beta adrenergic stimulation in sub endo cardial and sub epi cardial layers

Makdessi, S.A.; Andrieu J L.; Tuduri, A.; Timour Chah, Q.; Faucon, G.

Journal de Pharmacologie 13(2): 265-276


ISSN/ISBN: 0021-793X
Accession: 005010240

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The influence of .beta.-adrenergic stimulation on myocardium carbohydrate and lipid metabolism was compared with the influence of ischemia in the anesthetized dog heart in situ. Transmural samples necessary to the repeated determination of tissular substrates were taken from left ventricular wall according to the drill biopsy technique; they were made possible by a total cardiopulmonary by-pass system. The .beta.-adrenergic stimulation was obtained by infusion of isoproterenol (1 .mu.g/kg per min) and the ischemia by injection into left coronary artery before its division of a viscous mixture, reducing coronary flow by 40-70%. In subendocardial and subepicardial layers, but mainly in the former, the following was observed. .beta.-Adrenergic stimulation lowers glycogen content and raises lactate content immediately, lowers free fatty acid concentration more progressively without modifying triglyceride concentration significantly; and ischemia decreases glycogen content and increases lactate content in the same way, but raises free fatty acid and triglyceride concentration. .beta.-Adrenergic stimulation and ischemia are likely to add their effects on anaerobic glycolysis; they exert an opposite influence on lipid metabolism.