Comparison of passive haemagglutination and haemagglutination-inhibition techniques for detection of antibodies to rubella virus

Birch, C.J.; Glaun, B.P.; Hunt, V.; Irving, L.G.; Gust, I.D.

Journal of Clinical Pathology 32(2): 128-131


ISSN/ISBN: 0021-9746
PMID: 438343
Accession: 005010724

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Because of the technical problems and length of time involved in the satisfactory performance of the hemagglutination-inhibition test for detection of rubella-specific antibodies, a commercially available passive hemagglutination (PHA) kit utilizing rubella antigen-sensitized human erythrocytes was tested for its suitability for use in diagnostic laboratories. The immune response to acute rubella infections as measured by PHA was considerably delayed compared to the response measured by hemagglutination-inhibition. Titers of rubella-specific antibody only became comparable 6 mo. after the infection. The commercially available PHA kit is a useful addition to diagnostic laboratories for the determination of immune status and, in conjunction with the hemagglutination-inhibition test, can be an indicator of recent rubella infection.