Comparison of the anti hypertensive effect of a double dose of metoprolol vs. the addition of hydro chlorothiazide to metoprolol
European Journal of Clinical Pharmacology 25(5): 581-584
ISSN/ISBN: 0031-6970 Accession: 005013092
In 27 hypertensive patients whose blood pressure could not be adequately controlled with 200 mg metoprolol Durules alone, the effect of a double dose of metoprolol Durules (400 mg once/day) was compared with a fixed combination of 200 mg metoprolol and 25 mg hydrochlorothiazide (Selokomb). The study followed a double-blind cross-over schedule in 2 parallel groups. The reduction in diastolic blood pressure (P < 0.01) was comparable in the 2 groups. A significant fall (P < 0.01) in systolic blood pressure occurred with the metoprolol/hydrochlorothiazide combination. The subsequent change from the double dose of metoporlol Durules to the combination therapy also resulted in a fall in systolic blood pressure (P < 0.05). Mean serum K+ and blood glucose levels did not change after each alteration in therapy. Most of the side-effects mentioned were mild and transient in character.