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Comparison of the biological activity of the tumor promotor phorbol myristate acetate and a metabolite, phorbolol myristate acetate, in the cell culture

Comparison of the biological activity of the tumor promotor phorbol myristate acetate and a metabolite, phorbolol myristate acetate, in the cell culture

Cancer Letters 2(4-5): 285-289

ISSN/ISBN: 0304-3835

PMID: 45732

Phorbolol myristate acetate, a metabolite of the tumor promotor phorbol myristate acetate in mouse skin, has 1/50 the potency of the parent molecule for the induction of cell division in stationary cultures of BALB/c-3T3 mouse embryo fibroblast cells. In a mixed cell culture assay devised for detection of tumor promoting agents, phorbolol myristate acetate exhibited only a small fraction of the activity of unmetabolized phorbol ester. The biological activity of phorbol esters probably does not require metabolic conversion or may be converted by the cells used in this system. Phorbolol myristate acetate seems to be a tumor promotor of low potency for mouse skin compared to phorbol myristate acetate.

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Accession: 005013261

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Related references

Comparison of the biological activity of the tumor promotor phorbol myristate acetate and a metabolite, phorbolol myristate acetate, in the cell culture. Cancer Letters 2(4): 285-289, 1977

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