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Complement activation by aluminum and zirconium compounds

Complement activation by aluminum and zirconium compounds

Immunology 37(4): 881-888

The activation of [human] complement by a number of metal compounds, previously found to induce chronic inflammation, was investigated. Results obtained were compared with complement activation by inulin and zymosan. Complement activation by these metal compounds did not necessarily involve the classical or the alternative pathways. Some of these compounds were unable to activate complement in the absence of detectable plasminogen. A relationship was indicated between the ability of these compounds to induce chronic inflammation in the guinea pig and to activate complement.

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Accession: 005018946

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PMID: 500133

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