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Compounds with the trimethoxyphenylsulfonyl group iv. multivariate study of activity and structure activity relationships



Compounds with the trimethoxyphenylsulfonyl group iv. multivariate study of activity and structure activity relationships



European Journal of Medicinal Chemistry 21(3): 205-212



The CNS depressive activity of the 30 compounds with the trimethoxyphenylsulfonyl radical have been previously presented. Some of their chemical, physical and structural properties are now summarised. Their pharmacological activity is studied by the mean of 3 multivariate analyses. Principal Component Analysis shows clearly the pharmacology of this series. Cluster Analysis divides the compounds into 2 sets: active and less active. Step by step Discriminant Analysis applied to these 2 sets gives precise Structure-Activity Relations.

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Accession: 005024221

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