+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Computed chest tomography in rats with pulmonary damage due to microembolism

Computed chest tomography in rats with pulmonary damage due to microembolism

Acta Radiologica: Diagnosis 27(6): 723-728

Computed chest tomography was performed in 13 rats with pulmonary damage due to microembolism, caused by injection of thrombin (500 NIH/kg body weight) and tranexamic acid, a fibrinolytic inhibitor (200 mg/kg body weight), and in 9 control rats. The purpose of the investigation was to perform attenuation measurements at two levels of the right lung, each with three regions of interest (anterior, mid and posterior). Alterations in attenuation, compared with controls, were correlated with lung weight. Compared with controls, the attenuation was significantly increased in the anterior and posterior regions at both levels in animals with pulmonary damage, but not in the mid regions. There was a statistically significant correlation between increasing attenuation and increasing lung weight. A significant difference was found between damaged and control lungs regarding the microscopic grade of interstitial oedema, alveolar oedema and fibrin. Histograms of attenuation values in computed tomograms might be of value in detecting alveolar oedema. it is concluded that computed chest tomography is a good method for detecting pulmonary oedema at an early stage of experimental microembolism in the rat.

(PDF emailed within 0-6 h: $19.90)

Accession: 005024684

Download citation: RISBibTeXText

PMID: 3812023

DOI: 10.1177/028418518602700619

Related references

Combination of positron emission tomography/computed tomography and chest thin-layer high-resolution computed tomography for evaluation of pulmonary nodules: Correlation with imaging features, maximum standardized uptake value, and pathology. Medicine 97(31): E11640, 2018

Pulmonary artery hypertension associated with systemic scleroderma: correlation among lung pulmonary blood volume, lung perfusion single photon emission computed tomography, and chest computed tomography images. Circulation 127(1): 141-142, 2013

Flat-panel detector computed tomography imaging: observer performance in detecting pulmonary nodules in comparison with conventional chest radiography and multidetector computed tomography. Journal of Thoracic Imaging 27(1): 51-57, 2012

Can the "pine-needle sign" on computed tomography be used to differentiate pulmonary arteriovenous malformation from its mimics? Analysis based on dynamic contrast-enhanced chest computed tomography in adults. European Journal of Radiology 95: 314-318, 2018

Videodensitometry in rats with pulmonary damage due to microembolism. Acta Radiologica: Diagnosis 26(6): 785-788, 1985

Evaluation of the individual tube current setting in electrocardiogram-gated cardiac computed tomography estimated from plain chest computed tomography using computed tomography automatic exposure control. Nihon Hoshasen Gijutsu Gakkai Zasshi 69(5): 508-513, 2013

Chest Radiographs Can Minimize the Use of Computed Tomography of the Chest When Combined With Screening Scores for Pulmonary Embolism Evaluation. Chest Journal 142(4): 853a-853b, 2012

Detecting mediastinal lymph node metastases in non-small-cell lung cancer using a combination of technetium-99m tetrofosmin chest single photon emission computed tomography and chest computed tomography. Cancer Investigation 20(3): 311-317, 2002

Evaluation of chest radiography versus chest computed tomography in screening for pulmonary malignancy in advanced head and neck cancer. Journal of Otolaryngology 32(2): 107-109, 2003

Is chest x-ray or high-resolution computed tomography scan of the chest sufficient investigation to detect pulmonary metastasis in pediatric differentiated thyroid cancer?. Thyroid 14(3): 217-225, 2004

Pediatric pulmonary tuberculoma with a solid pulmonary nodule detected on chest computed tomography. Internal Medicine 53(8): 913-916, 2015

Increased pulmonary artery diameter on chest computed tomography can predict borderline pulmonary hypertension. Pulmonary Circulation 3(2): 363-368, 2013

Pulmonary high-resolution computed tomography versus gallium scintigraphy: diagnostic utility in the diagnosis of patients with AIDS who have chest symptoms and normal or equivocal chest radiographs. Journal of Thoracic Imaging 13(1): 52-57, 1998

Detection of non-aggressive stage IA lung cancer using chest computed tomography and positron emission tomography/computed tomography. Interactive Cardiovascular and Thoracic Surgery 19(4): 637-643, 2015

Prediction of pulmonary function after lung lobectomy by subsegments counting, computed tomography, single photon emission computed tomography and computed tomography: a comparative study. European Journal of Cardio-Thoracic Surgery 35(3): 408-413, 2009