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Computed tomographic evaluation of chronic ischemic lesions in cerebral white matter

Computed tomographic evaluation of chronic ischemic lesions in cerebral white matter

Japanese Journal of Geriatrics 18(5): 297-307

The correlation between the low density areas and periventricular lucency (PVL) on CT [computed tomography] and the histopathologic changes of chronic ischemic lesions in cerebral white matter was clarified. Thirty-seven brains from chronic cases with stroke and 17 brains from patients who showed PVL on CT were examined histologically. Chronic ischemic lesions with severe demyelination or diffuse cavitation were detected as low density areas on CT. If associated with severe gliosis, those lesions could not be detected on CT. Areas with myelin pallor could not be detected on CT. In some cases, diffuse ischemic lesions such as demyelination and cavitation were found in the areas corresponding to PVL on CT. They were not always expressed on CT. Other cases with PVL had no histological changes in the frontal white matter. Chronic ischemic lesions in the cerebral white matter could not always be detected as low density areas on CT. This may be partly because decreased density due to demyelination and cavitation was counterbalanced by severe gliosis which tends to increase the density. In some cases PVL were related to diffuse ischemic lesions in the frontal white matter, but this was not always the case.

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Accession: 005024952

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