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Concentration of serum immuno globulins in acute and chronic hepatic diseases part 1 serum levels of immuno globulin g immuno globulin a immuno globulin m and immuno globulin d in young patients with viral hepatitis



Concentration of serum immuno globulins in acute and chronic hepatic diseases part 1 serum levels of immuno globulin g immuno globulin a immuno globulin m and immuno globulin d in young patients with viral hepatitis



Revue Roumaine de Medecine Medecine Interne 17(1): 35-48



Concentrations of Ig[immunoglobulin]G, IgA, IgM and IgD were measured against WHO Reference Preparation 67/97 and British Standard 67/37 in sera from 105 patients with viral hepatitis and 110 current controls. To allow comparison at different ages and between sexes, constants previously determined on sera from a large laboratory group of controls were used to calculate scores for all Ig values. The patients' IgM scores were remarkably higher than those of controls and were bimodally distributed. About 68% of the patients had IgM scores more than 2 SD above the expected mean for laboratory controls. The distribution of IgG and IgA scores appeared unimodal, but shifted to the right of controls. The mean values of IgG and IgA scores were significantly greater in patients than in controls, and in female patients compared with males. IgG scores > 2 SD above the expected mean were found in 16% (12 of 73) of the male and 47% (15 of 32) of the female patients. With regard to IgD, no significant difference between patients and controls was observed.

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