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Conformational aspects of interactions of beta trypsin with substrates and pancreatic trypsin in inhibitor iii. the catalytic act of trypsin and its bovine pancreatic trypsin inhibitor inhibition


Conformational aspects of interactions of beta trypsin with substrates and pancreatic trypsin in inhibitor iii. the catalytic act of trypsin and its bovine pancreatic trypsin inhibitor inhibition



Molekulyarnaya Biologiya (Moscow) 20(2): 357-368



Basing on the results of the theoretical conformational analysis of the nonbonded and valence complexes of trypsin with substrate molecules, the catalytical act of the enzyme is described in this as a spontaneous process. Conformational aspects of interactions of trypsin with pancreatic trypsin inhibitor are analysed. The complete inhibition process and the geometry of the enzyme-inhibitor complex are described in details. The point amino acid replacements, which will provide for an exclusion of BPTI inhibition and will radically change the specificity of the enzyme are proposed.

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Conformational aspects of beta-trypsin interaction with substrates and pancreatic trypsin inhibitor. III. Catalytic act of trypsin and its inhibition. Molekuliarnaia Biologiia 20(2): 357-368, 1986

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