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Coronavirus in respiratory infection

Coronavirus in respiratory infection

Indian Journal of Medical Research 75: 323-328

Paired sera collected from 80 patients of respiratory tract infection were examined for coronavirus antibodies by single radial hemolysis (SRH), indirect hemagglutination (IHA) for antibodies to 229E virus and hemagglutination inhibition (HI) for antibodies to OC43 strains. Presence of antibodies against 229E virus was seen in 65% of the acute phase sera while 75% were positive for OC43. There was a good correlation between the results of SRH and either IHA or HI tests. Rise in antibody titer occurred in 12.5% of respiratory illnesses being observed only in cases of common cold or bronchitis; 8.8% a rise against 229E and 3.7% against OC43. Seroconversion to 229E occurred in 3 patients who had antibodies in the 1st serum sample. One child developed antibody response against both viruses. The infection rate was higher during the pre-summer months.

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Accession: 005057646

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PMID: 6286473

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