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Coronavirus infections of man associated with diseases other than the common cold

Coronavirus infections of man associated with diseases other than the common cold

Journal of Medical Virology 6(3): 259-266

About 14,000 paired sera, from patients with various types of acute infectious diseases with suspected viral origin, were screened by complement fixation against a wide set of viral antigens, including coronavirus OC43. A significant change in OC43 antibodies was recorded in 33 cases and a constant high titer, defined as a titer occurring in the respective age group in < 1% of all sera examined, was found in 45 cases. On the basis of careful retrospective analysis of hospital case records it was concluded that in 28 cases with an increase of OC43 antibody titers and in 2 with titer decrease a disease could be associated with an acute coronavirus infection. In 16 cases the disease was dominated by respiratory symptoms. Eight of these patients, 4 children and 4 adults, had pneumonia. Three of the 8 pneumonia patients had another concomitant infection too. Four patients had neurological symptoms, one had severe perimyocarditis and in 5 cases fever was the only symptom recorded. Among the patients with a statistically significant high titer of OC43 antibodies, there were 14 cases where a suggestive association with a disease could be envisaged on the basis of hospital records. Five of these patients had pneumonia. Human coronaviruses, so far considered only as 1 group of causative agents of the common cold may also be associated with other and more severe diseases in all age groups.

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Accession: 005057650

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PMID: 6262459

DOI: 10.1002/jmv.1890060309

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