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Correlation between spontaneous metastatic potential platelet aggregating activity of cell surface extracts and cell surface sialylation in 10 metastatic variant derivatives of a rat renal sarcoma cell line



Correlation between spontaneous metastatic potential platelet aggregating activity of cell surface extracts and cell surface sialylation in 10 metastatic variant derivatives of a rat renal sarcoma cell line



Proceedings of the National Academy of Sciences of the United States of America 77(7): 4336-4339



Several properties of 10 cell lines derived from the polyoma-induced PW20 Wistar-Furth rat renal sarcoma were examined, including the ability of the tumor cells to metastasize spontaneously from subcutaneous sites in syngeneic hosts, the platelet-aggregating activity of material extracted by urea from the surface of cultured cells, the sialic acid content of the platelet-aggregating material and the degree of sialylation of cell surface glycoconjugates in cultured cells. A correlation was observed among all of these parameters. The degree of cell surface sialylation of tumor cells, their ability to aggregate platelets, and their ability to metastasize may be linked.

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Accession: 005059653

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PMID: 6933486


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