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Coxsackievirus b infection in coronary care unit patients



Coxsackievirus b infection in coronary care unit patients



Journal of Clinical Pathology 36(6): 658-661



The incidence of myocardial infarction in coronary care unit patients and normal controls was compared. The choice of a suitable criterion for diagnosis of coxsackievirus infection is discussed. Admissions (250) to a coronary care unit and 100 control subjects had a serum sample tested by microneutralization for coxsackievirus B antibodies. The incidence of infection among 130 patients diagnosed as acute myocardial infarction was 5% compared with 4% in the control group. In a subgroup classified as non-transmural myocardial infarction, the incidence of infection was 14%. The sex ratio of this group differed from the myocardial infarction group as a whole, suggesting that the non-transmural group may not have been homogeneous. Normal coronary arteriograms were subsequently found in 3 patients who were diagnosed as non-transmural myocardial infarction, but who had serological evidence of recent coxsackievirus infection. No association between coxsackievirus infection and myocardial infarction; coxsackievirus infection does not cause or provoke myocardial infarction. Apparently, myocarditis may simulate non-transmural infarction.

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Accession: 005066335

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PMID: 6304150


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