+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Cyclophosphamide in the male rat behavioral effects in the adult offspring

Cyclophosphamide in the male rat behavioral effects in the adult offspring

Behavioural Brain Research 16(1): 25-36

Cyclophosphamide in a daily dose of 10 mg/kg was injected intraperitoneally in male Wistar rats for 15 days. Two rats each time were killed for testis examination at regular intervals within 100 days following treatment (over 2 spermatogenetic cycles). One hundred days after the end of the treatment, the other rats, whose spermatogenesis had recovered in the meantime, were mated with 3-month-old females. Offspring were evaluated in regard to the mean number per litter, sex ratio, frequency of gross external malformations, growth pattern, mortality in the first 4 months of life and reproductive ability at 6 months of age. Offspring behavior was also examined between 10 and 14 weeks of age. They were evaluated for spontaneous activity and emotionality with an open field test and for learning ability with an avoidance conditioning test. Cyclophosphamide induced a significant decrease in the number of primary spermatocytes and spermatozoa. Only learning ability was altered in the offspring from the treated males, for the animals which succeeded in the avoidance conditioning test did not learn as rapidly as the controls. However, the difference was significant only in the males. Behavioral abnormalities and the possible genetic factors involved are related to the particular concept of 'physioteratogenesis'.

(PDF emailed within 0-6 h: $19.90)

Accession: 005079842

Download citation: RISBibTeXText

PMID: 4040762

DOI: 10.1016/0166-4328(85)90079-8

Related references

Effects of maternal stress and perinatal fluoxetine exposure on behavioral outcomes of adult male offspring. Neuroscience 320(): 281-296, 2016

Antimitotic drugs (cyclophosphamide and vinblastine) in the male rat. Deaths and behavioral abnormalities in the offspring. Journal of Andrology 7(6): 378-386, 1986

Tumors and malformations in the adult offspring of cyclophosphamide treated and control male rats preliminary communication. Mutation Research 229(2): 239-246, 1990

Cyclophosphamide in the Fo male rat: physical and behavioral changes in three successive adult generations. Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis 229(2): 189-198, 1990

Effects of male cocaine us on behavioral attributes of F-1 offspring in rats. FASEB Journal 8(4-5): A631, 1994

Behavioral effects in offspring of male mice injected with opioids prior to mating. Pharmacology, Biochemistry, and Behavior 11 Suppl: 23-28, 1979

Effects of prenatal stress on immune and behavioral parameters in adult offspring. Society for Neuroscience Abstracts 26(1-2): Abstract No -179 2, 2000

Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F₂ male offspring via the F₁ male offspring. Journal of Applied Toxicology 36(1): 105-112, 2016

Effects of cyclophosphamide treatment of newborn mice on the development of swimming and reflex behavior and on adult behavioral performance. Developmental Psychobiology 9(6): 555-567, 1976

Effects of gestational stress: 2. Evaluation of male and female adult offspring. Brain Research 1302: 194-204, 2010

Cyclophosphamide in the male rat effect on offspring. Journal of Andrology 6(2 SUPPL): 60-P, 1985

Effects of maternal corticosterone and stress on behavioral and hormonal indices of formalin pain in male and female offspring of different ages. Hormones and Behavior 55(1): 149-157, 2008

Prenatal dexamethasone prevents early and long-lasting neuroendocrine and behavioral effects of maternal stress on male offspring. Fiziolohichnyi Zhurnal 54(5): 28-39, 2008