Section 6
Chapter 5,082

Cyto genetic features of quantitative distribution of thymus derived lymphocytes in human peripheral blood

Gurbanov, V.P.

Vestnik Akademii Meditsinskikh Nauk SSSR 4: 51-61


ISSN/ISBN: 0002-3027
Accession: 005081813

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In 15 normal donors, the features of quantitative distribution of associations by T-[thymus-derived]-lymphocytes were studied cytogenetically considering existence of 9 association types and 32 variants of their possible combinations in a cell. Statistical analysis revealed a good agreement between the quantitative distribution of associations and metaphases containing them. The hypothesis that the permanent quantitative composition of associations in a T-lymphocyte population is achieved by production of lymphocytes with the appropriate number and composition of associations was not refuted. Three subpopulations were distinguished among T-lymphocytes taking part in the immune response. An exponential law which agrees well with empirical quantitative distribution of subpopulations of lymphocytes containing associations of a similar type by the number of participating chromosomes was suggested. The peculiar quantitative distribution of lymphocytes in subpopulations was regarded as a feature of their formation justifying the differentiation of these subpopulations.

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