Cyto genetic studies of paroxysmal nocturnal hemo globinuria

Kuriya S I.; Dan, K.; Nomura, T.

Acta Haematologica Japonica 44(4): 839-844


Accession: 005082007

Download citation:  

Article/Abstract emailed within 1 workday
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Cytogenetic studies were carried out on the bone marrow and peripheral blood cells in 10 patients with paroxysmal nocturnal hemoglobinuria. In 1 case terminating in erythroleukemia an abnormal stem line with the karyotype of 49,XY, +8, +12, +17,t(17;21) (p11;q22) was detected in bone marrow aspirate and peripheral blood culture without addition of phytohemagglutinin. The frequency of aneuploid metaphases was remarkably high, 3.3-30.4%, in bone marrow aspirates from 7 additional patients. Most of the aneuploid cells were hypodiploid, loss of chromosomes being frequent in groups C, E and G. Aneuploidy was not found in peripheral blood cells cultured with phytohemagglutinin.