Cytotoxic effect of 5-fluorouracil plus cyclophosphamide against transplantable leukemias

Santelli, G.; Valeriote, F.; Vietti, T.; Coulter, D.

European Journal of Cancer 17(6): 629-634


ISSN/ISBN: 0014-2964
PMID: 7308260
Accession: 005083164

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The cytotoxic effect of the combination of cyclophosphamide and 5-fluorouracil against L1210 leukemia cells was quantitated by a spleen colony assay. Different sequences, a number of doses of each agent and different intervals between the agents were used; different degrees of synergistic cell-kill were noted. By proper scheduling of these agents, > 100-fold increase in cell killing was noted, an effect not demonstrable for normal hematopoietic stem cells. The pattern of response for AKR was opposite to that for L1210 leukemia; this probably reflects a difference in the metabolism of 5-fluorouracil.