Cytochemical characterization of hepatitis B virus infected liver cells in chronic liver diseases

Bencsáth, M.; Schaff, Z.; Lapis, K.; Keresztúry, S.; Kolláth, Z.; Hérics, M.; Hollós, I.

Acta Morphologica Academiae Scientiarum Hungaricae 29(2-3): 241-250


ISSN/ISBN: 0001-6217
PMID: 7315546
Accession: 005083847

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The cytochemical characteristics of hepatitis B virus (HBV) components and the nuclei and cytoplasm of the infected cells were studied in liver needle biopsy material obtained from patients suffering from serologically HBsAg staining the accumulation of granules 10-20 nm and 20-40 nm in diameter were observed in the liver cell nuclei. The cytochemical-morphological polymorphism of the latter was well detectable. Part of the granules corresponded to accumulated perichromatin granules. The group of granules 20-40 nm in diameter showing a varying density on DNP staining, similar to the chromatin on RNP staining, and not surrounded by a peripheral area probably represents 1 of the forms of the HBV core component.