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Cytogenetic effect of the natural modifiers of mutagenesis in a human lymphocyte culture effect of caffeine in the induction of chromosome aberrations by gibberellic acid

Arutyunyan, R.M.; Zalinyan, G.G.

Tsitologiya i Genetika 21(2): 101-105

1987

Accession: 005085302
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Caffeine sensibilization of the cytogenetic activity of gibberellic acid in the culture of human lymphocytes was investigated. A four-five-fold increase in the level of chromosome aberrations by addition of caffeine into the culture with gibberellic acid on the 29th, 46th and 72nd hour of cultivation was revealed. Application of sensibilizers of the chemical mutagens' action is recommended to study weak mutagenic activity of chemicals in routine test systems.

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Related References

Arutiunian, R.M.; Zalinian, G.G. 1987: Cytogenetic effect of natural mutagenesis modifiers in a human lymphocyte culture. The action of caffeine during the induction of chromosome aberrations by gibberellic acid Tsitologiia i Genetika 21(2): 101-105
Zalinian, G.G.; Arutiunian, R.M.; Sarkisian, G.G. 1990: The cytogenetic effect of natural mutagenesis modifiers in a human lymphocyte culture. The action of aminobenzamide during the gibberellic acid induction of chromosome aberrations Tsitologiia i Genetika 24(3): 31-34
Zalinyan, G.G.; Arutyunyan, R.M.; Sarkisyan, G.G. 1990: Cytogenetic effect of natural modifiers of mutagenesis in human lymphocyte cultures the action of 3 aminobenzamide in the induction of chromosome aberrations by gibberellic acid Tsitologiya i Genetika 24(3): 31-34
Movsesian, E.S.; Sarkisian, T.F.; Arutiunian, R.M. 1990: The cytogenetic effect of natural modifiers of mutagenesis in a human lymphocyte culture: the modification of the mutagenic effect by recombinant interferon in vitro in the lymphocytes of bronchial asthma patients and of healthy donors Tsitologiia i Genetika 24(2): 21-24
Arutyunyan, R.M.; Zalinyan, G.G. 1987: The modifying effect of caffeine on the cytogenetic activity of gibberellic acid in a culture of human lymphocytes Biologicheskii Zhurnal Armenii 40(2): 153-155
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Golub, E.V.; Sevan'kaev, A.V. 1995: The effect of inhibitors of DNA and protein synthesis on the yield of chromosome aberrations in a human lymphocyte culture under gamma and neutron irradiation at different stages of the mitotic cycle. The cytogenetic effects at the G1 stage Radiatsionnaia Biologiia Radioecologiia 35(5): 730-735
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