Daily rhythm of serum human chorionic gonadotropin and human chorionic somatomammotropin in normal pregnancy

Ayala, A.R.; Bustos, H.; Aguilar, R.M.

International Journal of Gynaecology and Obstetrics the Official Organ of the International Federation of Gynaecology and Obstetrics 22(3): 173-176


ISSN/ISBN: 0020-7292
PMID: 6148272
DOI: 10.1016/0020-7292(84)90001-8
Accession: 005090268

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The human chorionic gonadotropin (HCG) and human chorionic somatomammotropin (HCS) serum levels in normal pregnant women at 1-h intervals during 24 h, through radioimmunoassay procedures. The HCG levels were higher during the 1st trimester, although no circadian variations were detected. Some variations exceeded by 10-fold; these variations decreased with advanced periods of gestation. No diurnal fluctuations in serum HCS were apparent; in a case nearly at term, there was an increase from 0500 h to 0900 h simulating a circadian pattern, although it was not statistically significant. The placental protein secretion is autonomous and HCG levels of fluctuation during early stages of pregnancy might be regulated by factors other than the trophoblast.