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Demonstration of a syn carcinogenic effect of endogenous murine leukemia virus rescued from n methyl n nitroso urea induced leukemias and suboptimal n methyl n nitroso urea doses in mice



Demonstration of a syn carcinogenic effect of endogenous murine leukemia virus rescued from n methyl n nitroso urea induced leukemias and suboptimal n methyl n nitroso urea doses in mice



Neoplasma (Bratislava) 28(3): 265-270



The combined action of activated endogenous MuLV [murine leukemia virus] isolated from MNU[N-methyl-N-nitrosourea]-induced leukemias and suboptimal doses of MNU yields a significantly high incidence of leukemias and tumors in mice. Treatment with 1 agent alone shows little effect. The findings were discussed in view of the mechanisms in which viruses and chemical carcinogens interact in a syncarcinogenic process.

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Accession: 005103281

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