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Detection of specific immuno globulin m antibodies with the immuno globulin m fluorescent treponemal antibody absorption test and immuno globulin m treponema pallidum hem agglutination test in sero positive sera of syphilis patients



Detection of specific immuno globulin m antibodies with the immuno globulin m fluorescent treponemal antibody absorption test and immuno globulin m treponema pallidum hem agglutination test in sero positive sera of syphilis patients



Zentralblatt fuer Bakteriologie Mikrobiologie und Hygiene 1 Abt Originale A 254(4): 521-527



The IgM fraction was separated by gel filtration chromatography from patient sera which were positive in the FTA-abs [fluorescent treponemal antibody] and in the TPHA [T. pallidum hemagglutination] tests. After absorption, the isolated IgM fraction was tested for specific IgM antibodies against T. pallidum in the IgM-FTA-abs and IgM-TPHA tests. Both IgM tests often showed positive reactions even with negative results in the cardiolipin complement fixation assay (CFA). In most positive cases, specific IgM was detectable with both IgM tests in the same sample. The CFA titers were low (< 1:20) in the majority of cases which did not have detectable IgM. The CFA titers were prevailingly high (> 1:20) where the IgM tests gave positive results. Clinical symptoms of active syphilis were reported only for cases with high CFA titer and positive IgM tests in the same sample. Only these latter results of diagnostic tests can be clearly interpreted to indicate a requirement for specific therapy against syphilis.

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