Detection of trace amounts of trans di ammine di chloro platinum in the presence of cis di ammine di chloro platinum a high performance liquid chromatographic application of kurnakows test

Woollins, J.D.; Woollins, A.; Rosenberg, B.

Polyhedron 2(3): 175-178

1983


ISSN/ISBN: 0277-5387
Accession: 005119424

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Abstract
Treatment of mixtures of cis and trans Pt(NH3)2Cl2 with thiourea (thu) gave Pt(thu)4Cl2 and trans [Pt(NH3)2(thu)2]Cl2 which were separated and quantified by high-performance liquid chromatography using a strong cation exchange column. Several platinum-thiourea compounds were studied by NMR (1H, 13C, 195Pt), an increase in the coalescence temperature of the NH2 resonances being observed as a result of co-ordination. The NMR data was used to show the presence of interactions between the Pt(thu)42+ and PtCl62- ions of [Pt(thu)4][PtCl6] in dimethylsulfoxide solution. [cis-Pt(NH3)2Cl2 is an anti-tumor drug.].