EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Development of a systematic theory of suspension inhalation aerosols i. a framework to study the effects of aggregation on the aerodynamic behavior of drug particles






International Journal of Pharmaceutics (Kidlington) 27(1): 99-116

Development of a systematic theory of suspension inhalation aerosols i. a framework to study the effects of aggregation on the aerodynamic behavior of drug particles

When a suspension of drug particles is nebulized, the number of particles in a droplet depends on its size and on the relative sizes of the particles and the concentration of the suspension. Therefore, the drug particle size distribution after aerosolization is, in general, different from the distribution of the primary particles. The dry drug particles left after the evaporation of the propellant from a droplet form a cluster (aggregate). The average number of particles in such an aggregate and the variance of this number is calculated from the Poisson probability distribution function. Further progress is made under the following simplifying assumptions: (1) both the primary drug particles and the droplets are monodisperse; (2) the primary drug particles and the clusters are spherical; and (3) a particular model of packing of particles into aggregates can be adopted. The cumulative mass distribution of the drug as a function of the number of drug particles/cluster, equivalent volume and aerodynamic diameters are computed for a specific model. The ranges of concentration and ratios of droplet/particle diameters where aggregation is likely to affect significantly the aerodynamic behaviour of the drug, are outlined. The theoretical calculations are in qualitative agreement with the available experimental evidence for currently used therapeutic suspension inhalation aerosols. It is suggested that the treatment presented here may be developed into a predictive tool for formulation of aerosols with desired aerodynamic features.

(PDF 0-2 workdays service: $29.90)

Accession: 005132123



Related references

Development of a systematic theory of suspension inhalation aerosols ii. aggregates of monodisperse particles nebulized in polydisperse droplets. International Journal of Pharmaceutics (Kidlington) 41(1-2): 147-158, 1988

Suspension aerosols. II. Effects of drug containers on the aggregation of aerosol particles. Acta Poloniae Pharmaceutica 35(1): 81-85, 1978

Suspension aerosols. III. Effect of various surface-active agents on aggregation of particles. Acta Poloniae Pharmaceutica 35(4): 477-482, 1978

Effects of sampling chamber volume and geometry on aerodynamic size distributions of metered-dose inhalation aerosols measured with the Andersen cascade impactor. Pharmaceutical Research (new York). 11(4): 604-607, 1994

Investigation of the aerodynamic characteristics of inhaler aerosols with an inhalation simulation machine. International Journal Of Pharmaceutics (amsterdam). 130(1): 103-113, 1996

Optimized inhalation aerosols. I. The effects of spherical baffle size and position upon the output of several pressurized nonaqueous suspension formulations. Pharmaceutical Research 6(3): 225-229, 1989

Predicting Noninsulin Antidiabetic Drug Adherence Using a Theoretical Framework Based on the Theory of Planned Behavior in Adults With Type 2 Diabetes: A Prospective Study. Medicine 95(15): E2954-E2954, 2016

The generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles. International Journal of Nanomedicine 3(4): 435-449, 2009

Effects of extreme temperatures on drug delivery of albuterol sulfate hydrofluoroalkane inhalation aerosols. American Journal of Health-System Pharmacy 62(21): 2271-2277, 2005

Investigation of the dynamic process during spray-drying to improve aerodynamic performance of inhalation particles. International Journal of Pharmaceutics 390(2): 250-259, 2010