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Development of acute tolerance to pento barbital differential effects in mice

Development of acute tolerance to pento barbital differential effects in mice

Biochemical Pharmacology 28(4): 549-552

The present report deals with studies designed to ascertain whether the selective development of acute tolerance in C57BL mice was specific to ethanol or whether it would occur with other hypnotics such as pentobarbital. A demonstration that the difference between the 2 mouse strains was specific for ethanol would further support the use of these 2 strains in studies of tolerance to and physical dependence on ethanol. The results support the use of C57BL and DBA mice as animal models to determine the relationships between voluntary ethanol intake and neural sensitivity to the acute effects of ethanol, and the rates of development of tolerance to and physical dependence on ethanol.

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Accession: 005132228

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PMID: 426876

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