+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Development of adverse sequelae in children born with subclinical congenital Toxoplasma infection

Pediatrics 66(5): 767-774
Development of adverse sequelae in children born with subclinical congenital Toxoplasma infection
Most infants born with congenital Toxoplasma infection are asymptomatic in the newborn period, and therefore their infection is not recognized. We performed follow-up evaluations on 24 such children. The mean age of these children at least examination was 8.5 years. In group I (13 children), the diagnosis was made prospectively. In group II (11 children), no symptoms or signs were noted in the newborn period and the diagnosis was made only after the first sign developed. Eighty-five percent of the children in group I and all of the children in group II have developed chorioretinitis. In group I, three children (23%) have unilateral blindness; in group II, three children (27%) and five children (45%) have unilateral and bilateral blindness, respectively. One child (8%) in group I and two children (18%) in group II developed severe, permanent neurologic sequelae after they initially presented with eye disease. Two of the children in each group are now retarded (IQ score range, 36 to 62). Six of the children in group I who were tested sequentially have had lower IQ scores (mean change from 97 to 74) on repeat tests performed an average of 5.5 years later. Less severe neurologic, intellectual, and audiologic deficits were observed in other children in each group. Treatment of some children may have had a beneficial effect on their outcome.

(PDF same-day service: $19.90)

Accession: 005132259

PMID: 7432882

DOI: 10.1097/00006254-198108000-00013

Related references

Intellectual deficits in children born with subclinical congenital toxoplasmosis: a preliminary report. Journal of Pediatrics 82(5): 792-797, 1973

Survey of pregnant women and their new born infants for toxoplasma infection with special reference to frequency of the congenital transmission. Japanese Journal of Parasitology 23(6): 383-390, 1974

Toxoplasmosis and congenital infection human new born toxoplasma gondii intra cellular parasite fetal damage mental retardation chorio retinitis diagnosis. Birth Defects Original Article Series 4(7): 49-56, 1968

Antiviral antibodies and the development of sequelae in congenital CMV infection. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 35(0): 204, 1995

Why monitor infants born to mothers who had a seroconversion for toxoplasmosis during pregnancy? Reality and risk of subclinical congenital toxoplasmosis in children. Review of 30,768 births. Annales de Pediatrie 35(1): 5-10, 1988

Indices of physical development of children born of mothers with positive results of toxoplasma reactions. Wiadomosci Lekarskie 23(6): 441-444, 1970

Serological investigation on Toxoplasma infection of children with congenital birth defect. Chinese Journal of Schistosomiasis Control 19(2): 149-150, 2007

Study on relationship between Toxoplasma gondii infection and congenital disability in children. Chinese Journal of Schistosomiasis Control 16(6): 446-448, 2004

Human cytomegalovirus UL144 is associated with viremia and infant development sequelae in congenital infection. Journal of Clinical Microbiology 48(11): 3956-3962, 2011

Visual and auditory impairment in children with congenital cytomegalovirus and Toxoplasma gondii infection. Przeglad Lekarski 59 Suppl 1: 70-72, 2002